73 Milking of the Cut-Cord during Stabilization of Very Preterm Infants: A Randomized Controlled Trial (The MoCC Study)

Abstract Background Delayed cord clamping (DCC) for at least 30-60 seconds after birth has been recommended as the standard of care most preterm infants. However, DCC can be contraindicated or not optimal in certain situations (for example, cases interrupted placental circulation). Milking long-cut (MoCC) while providing stabilization and supporting breathing infant is proposed an alternative to DCC. Objectives To investigate feasibility MoCC during very infants birth. Design/Methods This parallel-group, randomized controlled trial was conducted IWK Health, which a tertiary perinatal centre Halifax, Canada. Infants born eligible, consenting women presenting labor <32 weeks’ gestation were group (where received 30 initial resuscitation steps taken by obstetric provider, followed milking one time over 10 seconds, with supported neonatal team) current group. For these infants, depended on whether baby not. Primary outcome terms percentage recruitment, intervention compliance, safety, study completion. Short-term clinical outcomes collected. Analysis intention-to-treat. Results Fifty either (25) (see Figure below). Baseline characteristics similar. All completed study. One five did receive allocated intervention. Median (IQR) 62 (54, 99) median length cut milked 20 cm (14, 29). associated adverse effects when compared Table). Conclusion DCC, breathing, feasible effects. A large required assess efficacy this approach outcomes. may especially useful immediate indicated. Potential competing interests Dr. El-Naggar served consultant Aerogen Pharma Limited site investigator its funded study: Partially-Blind, Randomized, Controlled, Parallel-Group, Dose-Ranging Study Determine Efficacy, Safety Tolerability AeroFactTM (SF-RI 1 surfactant inhalation combined dedicated drug delivery system) Preterm Risk Worsening Respiratory Distress Syndrome.